A Study On Breast Cancer - 2075 Words

Breast cancer is a disease that starts when an abnormal, uncontrolled cell growth occurs in the tissues of the breast. In a healthy body, cells grow, divide, and die in an orderly way, but once a damage or a mutation happens in the genetic material of the cell (which is found in the DNA) it results in cells that do not die. They continue to grow and divide uncontrollably and form abnormal cells that the body does not need. They can also metastasize, which means they invade other tissues through the bloodstream or lymph vessels. In contrast, in normal cells, when DNA is damaged the cell either repairs the damage or dies (Sudhakar 2009). Breast cancer has been known to mankind since the time of the ancient Egyptians, and there have been numerous theories throughout history. It was first mentioned as a bulging tumor that had no cure in the Ebers Papyrus (texts written on papyrus that included medical practices in ancient Egypt). In 460 B.C. Hippocrates described breast cancer as an hum oral disease that was caused by the excess of black bile. Thereafter, in 1680, Francois de la Boe Sylvius suggested that the cancer came from a chemical process that transformed lymphatic fluids from acidic to acrid (Sudhakar 2009). In 1757, Henri Le Dran suggested that surgical removal of the tumor and infected lymph nodes of the armpits could help treat breast cancer. By the 19th century, surgery was still the only available option for breast cancer and the development of antiseptic,Show MoreRelatedA Research Study On Breast Cancer1308 Words   |  6 PagesIntroduction Breast Cancer is on the fore-front of modern tumor research and scientists are continually seeking for new ways to treat and prevent cancer progression. Current treatments by hormone-dependent drugs like Tamoxifen and Raloxifene focus on estrogen receptor inhibition in mammary and endometrial cell lines. This group of drugs are known as selective-estrogen receptor modulators or SERMS, which are effective in estrogen-receptor positive (ER+) and hormone-estrogen receptor 2 positiveRead MoreBreast Cancer Case Study1306 Words   |  6 Pagesmetastases have caused substantial mortality and morbidity in cancer patients. Approximately 15% of women with breast cancer will be diagnosed with brain metastases (Zakaria et al., 2014). With early diagnosis and appropriate treatment, the quality of the patient’s life could be enhanced. Therefore, it is vital for patients with a known primary tumour to undergo imaging studies once they develop neurological signs and symptoms. Imaging studies aid to accurately identify the type, number, size, and locationRead MoreA Study On Breast Cancer843 Words   |  4 PagesBreast Cancer Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women (Up to Date, 2014). The associated risk can be as high as 12% for every woman in the United States, regardless of family history (American Cancer Society, 2013). For this reason, care begins with patient education, risk stratification, and preventative medicine. The paper will review preventative options, risk stratification based on genetics and age, and breast cancer treatmentRead MoreA Research Study On Breast Cancer1702 Words   |  7 PagesIntroduction Breast cancer is one of the leading causes of high mortality and morbidity in women population worldwide. Up to date, no effective breast cancer treatment has been developed and this has motivated academic scientists for the quest for alternative drugs and the discovery of drug targets. Increasing evidence suggests that carotenoids, which are micronutrients in fruit and vegetables, reduce breast cancer risk [1]. Previous findings suggest a protective role of ÃŽ ±-carotene, ÃŽ ²-carotene,Read MoreBreast Cancer Case Study929 Words   |  4 PagesIn the present study, we found that rate of pCR to neoadjuvant chemotherapy was 24.7% (n=25) in the whole cohort (n=101). This finding was consistent with the range of pCR rates to prospective randomized trials of preoperative chemotherapy of 15%-40% mentioned in the literature (Burstein et al., 2008). Moreover, high Ki-67 expression (cutoff 14%) was significantly correlated with achieving a pCR in the large cohort (p=0.016). This result matched with the finding of several studies that reported thatRead MoreA Research Study On Breast Cancer2138 Words   |  9 Pages Breast Cancer accounts for more than 20 percent of cancer in women, and is the primary cause of cancer death among women globally.1 Despite extensive scientific research on the disease, the outlook on a cure arguably remains poor. While some breast cancer survivors and women at high risk remain hopeful that soy intake will reduce the risk or even cure cancer, the recommendations are conflicting. For decades, the relationship between soy foods, supplements, phytoestrogen intake and cancer hasRead MoreBreast Cancer Case Study1234 Words   |  5 Pagesultimately lead to the progression of oral cancer. (Lee et al, 2010). c‑myc was among the first oncogenes found to be amplified in breast cancer, and it can contribute to many other forms of cancer (Victoria and Michael, 2007). It is a critical downstream effector of the Wnt/TCF pathway in colon cancer and activation of Myc might play a predominant role in the pathogenesis of tumors like pediatric hepatoblastoma (Sansom et al, 20 07; Cairo et al, 2008). A study done in south Indian population has shownRead MoreBreast Cancer Case Study803 Words   |  4 Pagessecondary organs fibronectin expression is upregulated by primary tumors via resident fibroblasts, which serves as a docking site for VEGFR1+ hematopoietic progenitor cell (HPC) clusters and secondary seeding. During metastasis of breast cancer to lung, interaction of VCAM-1+ cancer cells with VLA-4-expressing macrophages, activates PI3K/Akt signaling in tumor cells, protecting them from caspase-induced apoptosis. Bone metastasis is also facilitated by interaction of VCAM1 with different integrin partnerRead MoreA Research Study On Breast Cancer981 Words   |  4 PagesIn this case study we have Sarah a forty-two-year-old woman who has breast cancer which has metastasized to her lungs. Despite having had multiple tumors removed the cancer has returned. Sarah’s oncologist, Greg, recommends that she take part in a double blind experimental drug trial in an effort to slow the occurrence of more tumors. Greg explains that the risks of the drug are not entirely known; the drug won’t cure her cancer but may slow its progression, it may leave her extremely fatiguedRead MoreStudy On Breast Cancer Management Guidelines Essay1584 Words   |  7 Pages STUDY ON BREAST CANCER MANAGEMENT GUIDELINES ABSTRACT- Cancer is a big cause of death worldwide. Around the world Cancer of different types effect millions of population and leads to loss of lives. According to the available data through our complete and thorough nationwide registries on cancer (number of times something happens), number and death in India among males cancers of lung, mouth, oesophagus and stomach are leading places/locations of cancer and among females cancer of breast, cervix